Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection3회분의 BNT162b2 백신 또는 BA.1 감염에 의한 Omicron 하위 계통 및 Deltacron SARS-CoV-2 중화Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] Antibody neutralization BNT162b2 BNT162b2 vaccine contribute convalescent sera dose evade geometric mean geometric mean titre geometric mean titres GMT GMTs highest Identifier immune immune evasion individual infected individual infected individuals Infection Mutation neutralization neutralization activity neutralized of BNT162b2 omicron post-dose SARS-CoV-2 SARS-CoV-2 spike sera titre Trial registration unique USA-WA1/2020 vaccinated individual Vaccine variant variants variants. [DOI] 10.1080/22221751.2022.2099305 PMC 바로가기 [Article Type] Article
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering. Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylationArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while [DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기
Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome addition antibody Antiviral antiviral immunity characterization convalescent sera coronavirus coronavirus 2 coronavirus disease COVID-19 determine E484K elicited immune resistance immune resistance. individual induce induced Infection Mu variant Mutation notable resistance respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein the SARS-CoV-2 vaccination Vaccine variant [DOI] 10.1093/infdis/jiac053 PMC 바로가기
Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South KoreaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] baseline BNT BNT162b2 ChAdOx1 cohort study collected comparable conducted convalescent COVID-19 patients convalescent sera correlation COVID-19 COVID-19 pandemic COVID-19 vaccination cumulative Decreased Delta delta variant dose estimation explain groups HCW HCWs healthcare worker Heterologous highest homologous IQR Kinetics median Neutralizing neutralizing antibody Neutralizing antibody titer outbreak performed PRNT Protective protective immunity protocol SARS-CoV-2 sera serum sample significantly higher South Korea the mean vaccination vaccination. Vaccine development variants of concern VoC VOCs was used wild type wild-type SARS-CoV-2 WT SARS-CoV-2 [DOI] 10.3389/fimmu.2022.968105 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor TMPRSS2. Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology TestsArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adequate Analysis analyzed antibody antibody tests B.1 can be used caused characterized conserved convalescent sera COVID-19 COVID-19 patient cross-reactive cross-reactivity diagnostic domain ELISA test epitope global pandemic Humoral immunity immunogenic Infection magnitude new coronavirus SARS-CoV-2 nucleocapsid Nucleocapsid phosphoprotein patients positive correlation Protein raised RBD recombinant protein. reduced SARS-CoV-2 SARS-CoV-2 strain selective sensitivity sera serology test serology tests spike Spread Test the SARS-CoV-2 Vaccine variants of concern virus VoC VOCs [DOI] 10.3390/v14092041 PMC 바로가기
Factors associated with neutralizing antibody levels induced by two inactivated COVID-19 vaccines for 12 months after primary series vaccinationArticle Published on 2022-09-092022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] age analyzed anti-SARS-CoV-2 antibody BBIBP-CorV blood sample booster dose booster doses change Chi-square China convalescent convalescent sera CoronaVac COVID-19 COVID-19 vaccine cross-sectional Cytopathic effect dose enrolled evaluated Factor Factors FIVE geometric mean concentration geometric mean titer GMC GMT immune immune persistence immunogenicity Immunoglobulin inactivated individual influencing factors. linear models Logistic regression NAb neutralizing antibody NIBSC nine number ranged real-world data recipient recipients sample sizes SARS-CoV-2 SARS-CoV-2 strain seropositive Seropositivity Sex Standard subject understanding vaccination Vaccine Vaccines Vero Cell were measured WHO Zhejiang [DOI] 10.3389/fimmu.2022.967051 PMC 바로가기
IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2기억 B 세포에서 파생된 IgM 항체는 SARS-CoV-2의 강력한 교차 변형 중화제입니다Article Published on 2022-09-052022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] affinities affinity Antigen B cell receptor convalescent convalescent sera domain Donor donors Efficacy Epitopes highlight Humoral immunity IgG IgG antibodies IgG antibody IgM IgM antibody immune memory Immunity mAb mAbs memory memory B cell memory B cells monoclonal antibody monomeric neutralizing antibody neutralizing capacity pathogen polyclonal sera responsible retained SARS-CoV-2 SARS-CoV-2 viral therapeutic potential variant Viral while [DOI] 10.1084/jem.20220849 PMC 바로가기 [Article Type] Article
Neutralizing activity to SARS-CoV-2 in 1.2 to 10.0 month convalescent plasma samples of COVID-19: A transversal surrogate in vitro study performed in Quito-EcuadorCOVID-19의 1.2~10.0개월 회복기 혈장 샘플에서 SARS-CoV-2에 대한 중화 활성: 키토-에콰도르에서 수행된 횡단 대리 시험관내 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition analyzed binding domain BSL2 facility BSL3 caused convalescence Convalescent patients convalescent plasma convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determine diagnostic methods Ecuador glycoprotein IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M in some in vitro study Infection NAb NAbs neutralization test Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody performed plasma plasma. positive presence or absence Quito remained reported respiratory SARS-CoV-2 Seroconversion severe acute respiratory syndrome Coronavirus surrogate Test the SARS-CoV-2 Viral viral spike virus Wuhan Wuhan, China [DOI] 10.1002/jmv.27866 PMC 바로가기 [Article Type] Article